The Value of Immunoexpression of Phosphate and Tensin Homolog, Glucose Transporter-1 and (3 -Catenin in Endometrioid Carcinoma and its Precursor Lesions
نویسنده
چکیده
Background: Endometrial carcinoma is the most common malignancy in the female genital tract and associated with considerable degree of morbidity. Endometrial carcinoma has traditionally been divided into type I and type II cancers. Type I tumors are low grade endometrioid carcinoma that frequently arise in a setting of excess estrogen and associated with good clinical outcome while type II are high grade which have aggressive clinical course and hormone-independent pathogenesis. Aim of Work: To study the value of expression of phosphate and tensin homolog (PTEN), glucose transporter-1 (GLUT1) and (3 -catenin in endometrioid carcinoma and its precancerous lesions as predictive markers for endometrioid carcinoma. Methods: PTEN, Glut-1 and (3 -catenin expressions were evaluated using Immunohistochemical staining in 25 cases of endometrial hyperplasia and 25 cases of endometrioid carcinoma. Results: Positive PTEN immunoexpression was found in all cases of normal proliferative endometrium, 21 cases (84%) of endometrial hyperplasia, and 13 cases (52%) of endometrioid carcinoma with a highly statistically significant correlation between PTEN immunoexpression in endometrial hyperplasia and endometrioid carcinoma (p .value=0.013). All cases of normal proliferative endometrium, 19 cases (76%) of endometrial hyperplasia were negative Glut-1 immunoexpression while positive Glut-1 immunoexpression was found in 22 cases (88%) of endometrioid carcinoma with a highly statistically significant correlation between Glut-1 immunoexpression in endometrial hyperplasia and endometrioid carcinoma (p .value <0.001). Positive membranous (3 -catenin immunoexpression was found in all cases of normal proliferative endometrium and 23 cases (92%) of endometrial hyperplasia while no immunoexpression was found in endometrioid carcinoma. Positive cytoplasmic (3 -catenin immunoexpression was found in 13 cases (52%) of endometrioid carcinoma which was higher than found in endometrial hyperplasia and these findings were statistically significant (Mean: 41 vs 0; p<0.001). Positive nuclear (3 -catenin immunoexpression was Correspondence to: Dr. Mariem El-Fiky, The Department of Pathology, Faculty of Medicine, Zagazig University, Egypt found in 12 cases (48%) of endometrioid carcinoma which was higher than endometrial hyperplasia and these findings were statistically significant (Mean: 3 vs 0; p<0.001). Conclusions: Loss of PTEN expression as detected by immunohistochemistry is an informative biomarker for endometrial neoplasia. Lack of PTEN expression and GLUT1 overexpression are early events in tumorgensis of endometrioid carcinoma and the different patterns of expression of PTEN and GLUT1 were helped in distinguishing endometrial hyperplasia from endometrioid carcinoma. Cytoplasmic and nuclear (3 -catenin immunoexpression may be useful for a correct early diagnosis of of endometrioid carcinoma.
منابع مشابه
Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development
Endometrial carcinoma is the most prevalent gynecologic cancer in the United States. The tumor suppressor gene Pten (phosphatase and tensin homolog) is commonly mutated in the more common type 1 (endometrioid) subtype. The glucose-regulated protein 94 (GRP94) is emerging as a novel regulator for cancer development. Here we report that expression profiles from the Cancer Genome Atlas (TCGA) show...
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